Yaohong Wei¹, Wei Zhang², Sinclair Xinzhou Liu², Biao Han¹, Qi Chen¹; ¹South China Normal University, Guangzhou, China, ²Beijing Tsinghua Changgung Hospital, Beijing, China

Clinical semiology, waveform patterns, frequency band characteristics, and neuronal spiking activity exhibit notable reproducibility across seizures in the same patient. Drug-refractory focal epilepsy, recognized as a network disease, involves dynamic interactions across the epileptogenic zone (EZ), propagation zone (PZ), and non-involved zone (NIZ) during interictal, preictal, and ictal periods. However, whether these reproducible features distinctly delineate the EZ from the PZ and NIZ and the underlying temporal dynamics remain unclear. This study analyzed 14 patients with focal epilepsy characterized by low-voltage fast activity (LVFA), examining the reproducibility of raw signals, power spectra, and connectivity patterns during the interictal, preictal, and ictal periods across multiple seizures. Our findings reveal that neural activity and connectivity patterns in the EZ maintain high reproducibility across seizures. During the ictal phase, raw signals, power spectrum in delta (1–3 Hz) and gamma-to-ripple (30–250 Hz) bands, and connectivity patterns within the EZ demonstrated greater reproducibility than in the PZ, highlighting the stability of seizure generation and propagation mechanisms. Moreover, during the preictal phase, the power spectra of the beta band (14-30 Hz) and connectivity patterns within the EZ were both consistently more reproducible than those in the PZ. These findings enhance our understanding of epileptic network dynamics and may improve diagnostic precision and seizure modeling.